Ibuprofen and Other NSAIDs Reduce Antibody Response To Viral Infections.
Recently the French Health Minister warned everyone against taking NSAIDs because there was an associated greater risk of death in covid-19 patients. NSAIDs are commonly used for pain, chronic pain, headaches, and as an anti-inflammatory and/or fever reducer.
This paper explains a likely mechanism causing the increased death rates seen with taking these pain relievers.
“In conclusion, we report that a panel of widely used NSAIDs blunts antibody synthesis in human PBMCs and in purified B cells. Ibuprofen’s ability to reduce antibody production was concentration- and time-dependent and likely occurred via Cox-2 inhibition.
Our results call for awareness regarding the consequences that NSAIDs can have on immunity.
NSAIDs are one of the most commonly used drugs; they are recommended for all age categories, are prescribed for relieving transient pain or in cases of serious inflammatory diseases.
By decreasing antibody synthesis, NSAIDs also have the ability to weaken the immune system which can have serious consequences for children, the elderly and the immune-compromised patients.”
Reference:
Administration of ibuprofen during the first stages of inflammation can have repercussions on the immune system by interfering with optimal antibody production. Cell Immunol. Author manuscript; available in PMC 2010 Jan 1. Cell Immunol. 2009; 258(1): 18–28. 2009 Apr 5. doi:10.1016/j.cellimm.2009.03.007
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693360/
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